![]() Results Of 10 333 original and offspring participants in the Framingham Heart Study, 129 patients (72 women mean age, 77 years) experienced a primary ICH incident during a follow-up period of 68 years (301 282 person-years), with an incidence rate of 43 cases per 100 000 person-years. Nested case-control samples were used to examine baseline risk factors and medication exposures with the incidence of ICH events located in the lobar and deep brain regions within the 10 years before participants experienced a stroke event. Main Outcomes and Measures The unadjusted and age-adjusted ICH incidence rates, assessed in 3 periods (period 1, from 1948-1986 period 2, from 1987-1999 and period 3, from 2000-2016) to study incidence trends. No participant in the patient samples was excluded or approached for consent, as their initial consent to participate in the Framingham Heart Study included consent to follow-up of cardiovascular outcomes. Patients were matched by age and sex (1:4 ratio) with 396 individuals without any stroke event (the control group). After exclusions, the remaining 99 patients were divided into 2 nested case-control samples, which were created by stratifying the first incident of ICH by brain region (lobar ICH or deep ICH), with 55 patients included in the lobar ICH sample and 44 patients included in the deep ICH sample. ![]() A total of 129 participants were identified with a primary incident of ICH. Original and offspring patient cohorts were confirmed to have experienced a spontaneous ICH event through imaging or pathologic testing. Objective To assess long-term population-based trends in the incidence of ICH, examine incidence rates stratified by deep and lobar locations, and characterize location-specific risk factors.ĭesign, Setting, and Participants This longitudinal prospective community-based cohort study comprised 10 333 original participants (n = 5209 age range, 28-62 years) and offspring participants (n = 5124 age range, 5-70 years) from the Framingham Heart Study who were followed up from January 1, 1948, to December 31, 2016. Data regarding trends in ICH incidence and location-specific risk factors on the population level are conflicting. Importance Intracerebral hemorrhage (ICH) has the highest mortality of all stroke types and is the most serious complication of anticoagulation. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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